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Does Ibuprofen Raise Blood Pressure

A Closer Look At Acetaminophen

Does Ibuprofen affect blood pressure

The Swiss team set out to fill a surprising gap in medical knowledge: the effect of acetaminophen on blood pressure among people with coronary artery disease. This includes folks with angina along with anyone who has had bypass surgery or angioplasty or who has been diagnosed with cholesterol-clogged arteries.

The researchers asked 33 men and women with one or more of these problems to take either 1,000 milligrams of acetaminophen or an identical placebo three times a day for two weeks. Then, after a two-week break, each volunteer took the other treatment. The amount of acetaminophen used in the study is a standard daily dose for pain.

When the participants took acetaminophen, average systolic blood pressure increased from 122.4 to 125.3, while the average diastolic pressure increased from 73.2 to 75.4. Blood pressure stayed steady when participants took the placebo. These increases arent large. But they indicate that acetaminophen, like NSAIDs, somehow affects the cardiovascular system.

A larger, longer trial would have given more reliable results. It would also have been unethical, since none of the participants were in pain. That means they couldnt reap any benefit from acetaminophen, but could only be harmed by it.

Your Stomach Will Start To Hurt If You Take Ibuprofen Every Day

If you take ibuprofen every day, you just might find yourself doubled over with a tummy-ache.

One of the most common side effects that come from taking ibuprofen every day is stomach pain. And if you’re taking the pills daily on an empty stomach, you better believe your body won’t be thanking you for that. As noted by Everyday Health, as many as 50 percent of people who have tried ibuprofen for their aches and pains are unable to rely on the medication due to the abdominal pain, diarrhea, and other tummy troubles it causes them. So, if you’ve been popping ibuprofen like candy for a while, you might want to rethink that decision moving forward.

According to the Advil website, the NSAID can also cause “severe stomach bleeding,” which would call for a trip to the emergency room. Of course, if you’ve noticed slight discomfort after taking ibuprofen without food, it might help to eat a little something with the medication. However, if ibuprofen causes stomach pain even when taken with food, you should probably talk to your doctor about alternative medications, or scientifically proven natural remedies.

What Blood Pressure Medicines Do Not Cause Coughing

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Is Ibuprofen Bad For Your Heart

This common pain reliever may pose a heart risk for some. What you need to know.

Ive been taking ibuprofen for all my aches and pains for years, but I heard it can cause heart problems. Should I stop using it?

Ibuprofen is a common drug to have on hand for everything from headaches and toothaches to joint pain, muscle soreness and menstrual cramps. That said, doctors have actually known for years that taking nonsteroidal anti-inflammatory medications including ibuprofen and naproxenmay increase risk of heart attack and stroke. The U.S. Food and Drug Administration added a boxed warning about this issue to prescription nonaspirin NSAID labels back in 2005.

However, the FDA recently conducted a review of new research on NSAIDs. Based on this review, we now know that taking NSAIDs may pose a risk for heart attack and stroke earlier than previously thoughteven within the first few weeks of use. Whats more, the longer you rely on these drugs, the worse the risk may become. And if you take NSAIDs at higher dosages, you may also be more vulnerable. Thats why in July the FDA ordered drug manufacturers to beef up warning labels on Rx nonaspirin products, and will request that makers of over-the-counter nonaspirin products update the info on their labels, too.

And keep in mind that you can always start with nondrug options, like hot or cold packs or massage, to help ease your pain.

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More Tips For Avoiding Medication Problems

Does Ibuprofen raise Blood Pressure?

Be sure any medications you choose to use are safe for people who have high blood pressure. These suggestions can help:

  • Give a list of ALL the medications you use, both prescription and over-the-counter, to every doctor you visit.
  • Read medication labels before buying over-the-counter products. Make sure the medicine doesn’t contain ingredients that could make your high blood pressure worse, such as NSAIDs or decongestants.
  • Talk to your doctor before using any over-the-counter medication, herbal preparation, vitamins, or other nutritional supplements. Ask for alternatives to potentially harmful medicines.

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Ibuprofen And High Blood Pressure

Q. My doctor prescribed 800 mg of ibuprofen a couple of times a day for the pain and inflammation of a severely twisted knee. When I took my blood pressure a few weeks later it was 180/96. Thats much higher than my usual 124/76.

That scared me, so I searched your website for answers. I discovered that ibuprofen and high blood pressure can go together. What else can I use for the pain?

How Ibuprofen Raises Blood Pressure

NSAIDs such as ibuprofen, naproxen and diclofenac work by blocking enzymes that regulate the production of hormone-like prostaglandins. Prostaglandins are produced in platelets and in blood vessel walls, and play a role in blood vessel dilation and kidney function, as well as having a damping down effect on inflammation and pain.

These NSAID painkillers cause blood pressure to rise by increasing the sensitivity of blood vessels to the constricting effects of stress hormones. NSAIDs also neutralise the blood pressure lowering effects of some antihypertensive drugs, and increase the risks associated with having uncontrolled high blood-pressure such as heart attack, stroke and heart failure.

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Alternatives For Pain Relief

If you do not want to take pain medications for relief of headache or other mild aches and pains, there are other alternatives. Many people find that ice packs and heating pads can bring relief. Relaxation techniques like meditation, imagery, or yoga can be used to help manage pain. Physical activity may help with some kinds of pain, like that of arthritis. Finally, acupuncture and other nontraditional techniques can help some people with mild to moderate pain.

If You Have Type 2 Diabetes


There are few factors that you should consider if you have type 2 diabetes and are wondering if its okay to take a couple of ibuprofen for your headache, backache, or fever.

Metformin use

Many people with type 2 diabetes take metformin to help them control their blood sugar levels. Metformin belongs to a class of drugs known as biguanides.

Metformin lowers the amount of glucose that your liver makes and the amount of glucose that you absorb from the food you eat. It also has some anti-inflammatory effects. Some research suggests that metformin may interact with ibuprofen and other analgesics.

One 2017 study suggested that they actually interacted synergistically and that lower doses of ibuprofen would be adequate for a person already taking metformin to get the pain relief they needed. But that study was conducted with animals, and more research is needed.

Chronic kidney disease

You may also need to steer clear of ibuprofen if you have kidney disease. A large retrospective published in 2014 found that people with type 2 diabetes who took NSAIDs for at least 90 days were more likely to develop chronic kidney disease than people who didnt take any NSAIDs.


suggests that people who are receiving treatment with sulfonylureas, which is used to stimulate the beta cells in your pancreas to release more insulin, might be at increased risk for hypoglycemia.

Since sulfonylureas can potentially lead to low blood sugar anyway, ibuprofen might compound the effect.

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Taking Ibuprofen Every Day Could Lead To Kidney Disease

Taking ibuprofen every day could negatively impact the healthy of your kidneys.

In case you didn’t know, your kidneys are pretty important organs. As noted by the National Kidney Foundation, your kidneys work to remove waste from your body, and also produce important hormones your body needs. Anyone can see why it’s important to keep your kidneys healthy however, just like your go-to snacks are some of the worst foods for your kidneys, your go-to pain medicine just might be one of the worst medications for your kidneys. In fact, if you take painkillers like ibuprofen on a regular basis, your kidneys could get sick.

According to the National Kidney Foundation, longterm, habitual use of medicines like ibuprofen, naproxen, and high doses of aspirin can cause chronic interstitial nephritis a disease in which the spaces between the kidney tubules become inflamed . While sporadically taking ibuprofen in recommended doses shouldn’t hurt your kidneys, medicines like Advil and Motrin should probably be avoided if you already have kidney-related diseases or other issues.

Only 12% Of Consumers Are Aware Ibuprofen May Interfere With The Cardioprotective Benefits Of Aspirin1

Ask patients about aspirin heart therapy before recommending ibuprofen

  • Your patients may not realize that their choice of OTC pain reliever may have consequences, depending on their health conditions and other therapies, including aspirin heart therapy regimen. Your guidance can help.

  • Below is a list of potential drug interactions and contraindications to consider before recommending ibuprofen. It is not a substitute for the full OTC Drug Facts label. Patients should always read and follow the product label for additional product information.

1. Coexisting medical conditions to consider before recommending OTC ibuprofen


  • Patients with cardiovascular disease are at increased risk for cardiovascular events when taking a non-aspirin NSAID such as ibuprofen or naproxen sodium2.

  • For patients on an aspirin heart therapy regimen, ibuprofen may interfere with the cardioprotective benefit of aspirin3.

Recent FDA NSAID label updates with respect to CV risks4:


  • Patients over age 60 and patients with existing GI risks who take ibuprofen or any other NSAID are at higher risk of developing serious GI toxicities such as an ulcer or bleeding.


  • Patients with renal dysfunction who take ibuprofen or other NSAIDs may develop chronic kidney disease5. NSAID-related renal adverse events may be dependent on dose and duration of therapy, and can include reduced glomerular filtration, nephritic syndrome, and chronic renal failure6.


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Does Advil Increase Your Blood Pressure

Does Ibuprofen Raise Blood Pressure

Q: Does Advil usually increase ones blood pressure?

A: Advil is in the class of drugs known as a non-steroidal anti-inflammatory drug. This type of drug can cause an increase in blood pressure. Blood pressure typically returns back to baseline when the drug is stopped. For those who take ibuprofen occasionally for a headache or muscle soreness, the temporary elevation in blood pressure is not significant.

More about over-the-counter pain reliever drugs and impact upon high blood pressure.

  • john ayresPosted November 22, 2012 at 8:18 PM

    Most articles seem to lump all NSAIDS together when it comes to health risks. If you dig back to real scholarly studies, it turns out that there are increased risks with all but naproxen which stands out as having practically no effect on outcomes at all. So that is my choice.I dont know why these studies dont get an airing

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    What Else Raises Blood Pressure

    Other factors may also trigger an increase in blood flow. The following can raise blood pressure:

    • Age: The risk of hypertension increases as you age.
    • Family: You are more likely to get high blood pressure if it runs in your family.
    • Already having another disease:Unmanaged diabetes, heart disease, thyroid, kidney, and autoimmune conditions may cause high blood pressure.
    • Having clogged arteries:Damage to blood vessels may change their structure and increase blood pressure.
    • Diet:Diets high in sugar and sodium can increase blood pressure.
    • Lifestyle choices:Low physical activity, smoking, moderate alcohol intake, and not getting enough sleep are associated with high blood pressure.
    • Mental health:Loneliness, stress, anxiety, and anger have been linked to increases in blood pressure.
    • Your self-esteem: Low-self esteem and negative self-talk are harmful to blood pressure.
    • Medications: NSAIDs , decongestants, hormonal birth control, and antidepressants are medications that can increase blood pressure.
    • Hydration status: Not drinking enough water can cause high blood pressure.
    • Holding the bladder: Putting off urinating for long periods of time may cause high blood pressure.

    Does Ginger Raise Blood Pressure

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    Ibuprofen More Likely To Raise Bp Than Naproxen Or Celecoxib

    NEW YORK Ibuprofen boosts blood pressure more than naproxen or celecoxib in patients who take non-steroidal anti-inflammatory drugs to treat arthritis, according to a new substudy from the PRECISION trial.

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    These drugs are different with regard to BP, and ibuprofen is the worst, Dr. Frank Ruschitzka of University Hospital Zurich in Switzerland, the studys first author, tells Reuters Health.

    In 2015, the U.S. Food and Drug Administration strengthened its warning on the cardiovascular risks of over-the-counter NSAIDs and cyclooxygenase 2 inhibitors, Dr. Ruschitzka and his team note in their Aug. 28 online report in the European Heart Journal.1 Clinicians face difficult decisions on how to treat patients who take NSAIDs regularly to treat arthritis, they add, many of whom also have hypertension.

    The PRECISION randomized trial, funded by celecoxib maker Pfizer and mandated by the FDA, compared the three drugs in patients with arthritis who either had cardiovascular disease or were at increased risk. Published in the New England Journal of Medicine in 2016, PRECISION showed that celecoxibs cardiovascular safety was non-inferior to that of naproxen or ibuprofen.

    In the new PRECISION prespecified substudy, 444 arthritis patients underwent 24-hour ambulatory BP monitoring at baseline and after four months on celecoxib , ibuprofen or naproxen . Mean baseline BP was 125/75 mmHg and very similar among the groups.

    What Painkiller Can I Take With High Blood Pressure

    Does Meloxicam cause high blood pressure

    In general, people with high blood pressure should use acetaminophen or possibly aspirin for over-the-counter pain relief. Unless your health care provider has said its OK, you should not use ibuprofen, ketoprofen, or naproxen sodium. If aspirin or acetaminophen doesnt help with your pain, call your doctor.

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    Who Treats Postural Orthostatic Tachycardia Syndrome

    In many cases, your primary care physician is qualified to treat POTS. For complex POTS cases, it is often helpful to have input from a neurologist or cardiologist experienced in this condition. Rehabilitation physicians can help as well in developing an exercise plan that works for you.

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    Reader Question: Will Acetaminophen Raise Blood Pressure

    Q: I have taken NSAIDs for pain relief, but they bump up my blood pressure. I had some dental work done, and I took Advil for the throbbing pain. When I checked my blood pressure, it had spiked about 40 points over my usual number.

    Is Tylenol less likely to be a problem? I try to avoid pain meds as much as possible, but occasionally I have to take something.

    A: Nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen can raise blood pressure . Pain can also increase BP.

    The makers of Tylenol are advertising that their pain reliever wont raise blood pressure the way that Advil, Aleve or Motrin sometimes can. That sounds reassuring, but you will notice that the commercial does not say acetaminophen wont raise blood pressure at all.

    Researchers have found that both acetaminophen and NSAIDs independently increase the risk of hypertension in women . There is also a similar association in men .

    Occasional use may not pose a problem. Aspirin does not appear to increase blood pressure the way other NSAIDs do.

    To help you avoid other things that can contribute to high blood pressure, you may find our eGuide to Blood Pressure Solutions helpful. This online resource is available in the Health eGuides section at

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