H2s Production And The Effect Of Garlic On Hypertension
A second vascular gaseous signal transmitter is H2S. H2S exists in micromolar concentrations in various mammalian tissues, including the brain, nervous system, vascular smooth muscle cells, and in the heart. Endogenous H2S production is primarily the result of two enzymes: cystathionine–synthase and cystathionine–lyase , whereby the nonessential amino acid cysteine is metabolized by desulfuration, releasing sulfur in a reduced oxidation state and generating H2S. In addition, 3-mercaptopyruvate sulfur-transferase and cysteine aminotransferase localized to the endothelium of the thoracic aorta have also been reported to produce H2S from cysteine and -ketoglutarate. Experiments with CSE knock-out rodents have found reduced levels of H2S and hypertension. Also, spontaneously hypertensive rats have reduced expression of CSE in aortic tissues and lowered plasma levels of H2S.,,
illustrates the H2S production pathway, the connection to the methylation cycle and homocysteine , the effect of H2S on vasodilation, and influence of garlic-derived polysulfides on this pathway.
Effect of garlic on blood pressure via the hydrogen sulfide pathway, and influence of dietary and genetic factors on homocysteine levels.
The H2S-dependent BP-reducing effect is thought to be primarily mediated through sulfhydration of ATP-sensitive potassium channels, which in turn leads to voltage-sensitive channel opening and relaxation of vascular smooth muscle cells.
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Potential Risks Of Garlic
The primary side effect of garlic consumption is its blood-thinning properties. If you dont usually eat garlic, you may want to check with your doctor before adding it to your diet.
Excess Bleeding
Because garlic can make blood less likely to clot, you should stop eating it 7 to 10 days before any surgery you have planned.
Drug Interactions
Avoid garlic if you’re already taking an anticoagulant, such as Coumadin or Heparin, because the blood-thinning action of the medication may be increased.
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Contraindications Adverse Effects Interactions
The ingestion of one to two cloves of raw garlic per day is considered safe in adults. The most common side effect of ingested garlic is breath and body odor. Consumption of excessive amounts of raw garlic, especially on an empty stomach, can cause gastrointestinal upset, flatulence, and changes in the intestinal flora.1,10 There have been reports of allergic dermatitis, burns, and blisters from topical application of raw garlic.10
Garlic appears to have no effect on drug metabolism,22 although recent studies23,24 in healthy volunteers show conflicting results related to garlics effect on protease inhibitor pharmacokinetics. It has been suggested that patients taking anticoagulants use caution when taking garlic because of its antithrombotic properties.10,22 It seems prudent to stop taking high dosages of garlic seven to 10 days before surgery because garlic can prolong bleeding time and has been associated with spontaneous spinal epidural hematoma.10,25
So Is Garlic Good For Blood Pressure Yes
Eat garlic every day if you can. Aim to use at least a couple of cloves a day. Try chopping it up finely and putting into salad dressings . As well as being most tasty, you get the most benefit from using it raw.
You can use lots of garlic in raw salsas too mix it in with lots of chopped onions, tomatoes, chillies, lime juice , and a lot of fresh coriander/cilantro.
Plus, use it in as much of your cooking as you can too! It works in almost every type of food. If you like roasts, put in a few whole garlic cloves. They become deliciously soft and rich and tasty.
Yes, garlic is smelly, but as long as those close to you eat plenty too, youll never notice each others garlic breath! Seriously though, the smell is part of the benefit. Or rather, the sulphuric compounds which cause the smell are. For a while, all the health benefits of garlic were put down to a substance called allicin. However, now its recognised that the smelly sulphuric compounds also contribute to garlics beneficial effects.
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Garlic Extract Or Supplements
Garlic supplements are available in various forms, such as tablets, oils, powders, aged garlic extract, and pure allicin. Garlic supplements are considered better than other forms of garlic since they contain high amounts of the active compounds. Studies suggest that aged garlic extract is effective and tolerable in the treatment of uncontrolled high blood pressure.
Three Reasons A Heart Loves Garlic
Research shows that garlic has many different health benefits, including some that can help your heart.
- Garlic is an excellent source of antioxidants, which can help fight infection and cell damage.
- Several studies have shown that garlic can help lower blood pressure.
When it comes to lowering your cholesterol and improving heart health, there are a lot of foods that can help. But if you’re looking for a way to add flavor to a dish while also helping your heart, garlic may be the answer.
Some studies have shown that garlic and garlic supplements may have positive effects on heart health by preventing cell damage, regulating cholesterol and lowering blood pressure. Other research shows that garlic supplements may also reduce plaque buildup in the arteries.
Don’t let something like a little garlic breath scare you away from this superfood. Here are a few benefits to adding garlic or garlic supplements to your diet:
1. Helps boost your immune system and protect cells
Our bodies need antioxidants to help prevent or slow cell damage caused by unstable molecules called “free radicals.” Free radicals can be naturally occurring in the body or can come from external sources such as radiation exposure, smoking, air pollution or chemicals. Too many free radicals can lead to oxidation stress, a condition linked to chronic illnesses, including heart disease.
2. Helps lower your blood pressure
3. Helps combat atherosclerosis
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Garlic In Your Dinner
Perhaps for these reasons, experts say the best way to get your garlic is from the fresh clove, although there can be a few side effects from eating it fresh. Garlic breath is probably the worst of it, but some people do suffer from indigestion after eating fresh garlic.
A less stinky and easier-on-the-stomach alternative may be black garlic, which is “aged” under intense heat and humidity for 10 days, turning the bulbs black and purportedly giving the allium a sweeter, more sour taste with a jelly-like consistency. This aging process rids the garlic of its pungent, irritating properties, but the benefits remain.
Garlic is an essential part of the Mediterranean diet, “which has been shown to have the best long-term outcomes of any diet we know of, says Budoff. Studies have linked this way of eatingwhich emphasizes produce, legumes, grains, and healthy oils, with small amounts of fish and meatto a better quality of life, a lower risk of chronic disease, and better brain health in older adults.
I use garlic in a lot of recipes, says Ellen Klosz, a Consumer Reports nutritionist. You can use it to spice up a healthy dish without having to add any salt. Just make sure to use fresh garlic instead of garlic salt, which will boost the sodium levels.
Garlic For High Blood Pressure Symptoms Relief
As the body increases the production of an enzyme called angiotensin I-converting enzyme, or ACE, blood pressure increases. Pharmaceutical drugs called ACE inhibitors work by blocking the formation of this enzyme, but they have multiple side effects. Garlic contains gamma-glutamylcysteine, a natural ACE inhibitor. This chemical, in combination with the high allicin content, gives garlic its ability to dilate arteries, thereby lowering blood pressure.
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Garlic May Support Immune Function
Given our collective zest for learning about taking care of our immune system during the COVID-19 pandemic, heres one reason to add garlic to your dinner tonight. While theres not enough evidence to suggest that that garlic will prevent or treat the common cold, for instance, it can play a role in your bodys defense mechanisms in a few ways.
For one, the allicin in garlic provides antibacterial properties, says Bazilian. Scientists also believe that garlic has antiviral properties that may work in two ways, she says: by blocking the entry of viruses into cells, and by strengthening the immune response so that it can effectively fight off potential invaders. Its these things that can help support a healthy immune system overall.
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More Reasons To Love Garlic
Garlic’s benefits don’t just stop with the heart. Here are some other reasons why your body may appreciate an extra dose of this onion family member.
Cancer prevention
Research suggests eating fresh garlic may help reduce the risk of colorectal cancer. The Iowa Women’s Health Study showed that women who regularly included garlic in their diet had a 35% reduced risk of developing colon cancer. However, researchers agree that more studies are needed in this area.
Antimicrobial properties
Garlic contains the antimicrobial allicin, which can help fight off pathogens and bacteria. While all members of the onion family have some form of this antimicrobial, garlic has the highest amount.
More information is needed to determine if there are any possible bacteria-fighting effects of garlic. However, a 2018 study showed that garlic essential oil might help fight Lyme disease bacteria.
Fighting the common cold
Some studies suggest eating garlic helps ward off the common cold. It may also help reduce overall symptoms and shorten your bout with the coughs and runny noses associated with colds.
Mechanisms For Blood Pressure
Several mechanisms of action for the BP-lowering properties of organosulfur compounds in garlic have been postulated, including mediation of intracellular nitric oxide and hydrogen sulfide production as well as blockage of angiotensin-II production, which in turn promotes vasodilation and thus reduces the BP.
The strongest evidence of and insights into the mechanisms of the BP-lowering effect of garlic supplementation involve endothelium-dependent vasodilation, and thus, this review will focus on the current knowledge of the physiological and biochemical processes within blood vessels.
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What About Garlic And Cholesterol
While some studies have shown that garlic can benefit cholesterol levels, more research is needed. In particular, scientists are looking to learn more about its long-term effect on cholesterol and the heart.
Cholesterol is a waxy substance that circulates in your blood. There are two types of cholesterol: “bad” cholesterol, or LDL cholesterol, and “good” cholesterol, or HDL cholesterol. Having too much LDL cholesterol and low levels of HDL cholesterol in your blood can raise your risk for severe health problems.
A 2016 study published in the International Journal of Preventive Medicine concluded that a garlic-lemon juice mixture may benefit cholesterol. The small study, which involved 112 people ages 30-60, showed that garlic and lemon juice helped decrease total cholesterol and lower blood pressure. However, researchers recorded the results after only eight weeks.
An analysis of studies done between 1955-2013 also showed that garlic “moderately to significantly” lowers total cholesterol and LDL cholesterol levels. When taken for more than two months, the garlic helped reduce total cholesterol by 8%.
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Reninangiotensinaldosterone System And The Effect Of Garlic On Hypertension
Other potential mechanisms of action for garlics effect on hypertension have been proposed, including the potential of garlic blocking angiotensin-II production by inhibition of the angiotensin-converting-enzyme , as suggested in a number of cell culture and animal studies.,, ACE is a component in the reninangiotensinaldosterone system, and inhibitors of ACE are used as standard BP-controlling pharmaceuticals. However, animal and cell culture experiments were mainly conducted with fresh garlic compounds, containing allicin , which has a very low sustained bioavailability in human tissues. Therefore, the antihypertensive effect of garlic via the proposed angiotensin-converting enzyme inhibitor mechanism seems less plausible than its H2S-stimulating and NO-regulating properties.
Potential Health Benefits Of Garlic
Medical research links garlic to a number of health benefits. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. Garlic tea retains the health benefits of raw garlic, as long as it is prepared properly: the key is boiling your crushed garlic no longer than 3 minutes.
Cardiac Health
Researchers at Emory University School of Medicine found that a component of garlic oil, diallyl trisulfide, helps protect the heart after a heart attack and during heart surgery. Mice that received this component after a heart attack had 61% less damage to the affected cardiac tissue than untreated mice.
The research also suggested that the component could reduce heart enlargement in a mouse model of heart failure. Further research is needed to understand the effects on humans.
Garlic supplements, and in particular aged garlic extract, have also been shown to reduce blood pressure in people with hypertension. It appears to do so in part by preventing vasoconstriction, or narrowing of blood vessels. While garlics effects are comparable to standard blood-pressure drugs, it has been found that people who have inadequate levels of vitamin B may not experience this benefit.
Continued
Reduced Risk of Infections
Reduced Blood Clotting
Reduced Risk of Cancer
Continued
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