B Vitamins B9 B6 And B2
B vitamins are a class of vitamins that play different roles in cell function and blood formation. There are eight B vitamins in total, but only three have a bearing on hypertension, namely:
Vitamin B9, also known as folate, is essential for blood formation and cell growth. Folate supplementation can help reduce blood pressure by promoting blood flow and helping blood vessels relax.
Folic acid is an antioxidant that helps reduce oxidative stress that impairs the function of nitric oxide, thereby reducing blood pressure.
One study¹² showed a significant decrease in systolic pressure in hypertensive patients after taking folate supplements for six weeks. On the flip side, very little to no change was noted in diastolic pressure.
Animal studies¹³ show that vitamin B6 can reduce blood pressure, although no human studies have been conducted to prove the theory. Scientists presume that since low levels of vitamin B6 are prevalent in hypertensive patients, maintaining an adequate intake of this vitamin can help prevent the development of the disease.
Vitamin B2, also known as riboflavin, has been shown to lower blood pressure¹ in people with a methylenetetrahydrofolate reductase gene mutation. The MTHFR gene is responsible for the synthesis of folate, which facilitates normal blood flow and blood vessel health.
Natural sources of B vitamins
Different foods have different B vitamins. Natural sources of vitamin B9 include:
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Green leafy vegetables
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Resveratrol And Grape Seed Extracts
Resveratrol is a polyphenol that is particularly concentrated in grape. Many studies have shown the antihypertensive effects of resveratrol in different preclinical models of hypertension, through a multitude of mechanisms that include its antioxidant properties, the stimulation of endothelial NO production, the inhibition of vascular inflammation and the prevention of platelet aggregation 69.
In a metaanalysis of six RCTs, comprising a total of 247 subjects, only higher doses of resveratrol significantly reduced SBP, by 11.9 mmHg P = 0.01 70.
A metaanalysis of nine doubleblind, placebocontrolled RCTs, including 390 subjects, showed that grape seed extract slightly but significantly reduced SBP ) but not DBP 71.
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Magnesium For High Blood Pressure
Magnesium assists in the regulation of many systems of the body. It aids in the production of nitric oxide, which relaxes blood vessels. As a result, some people speculate that magnesium supplements may lower blood pressure. The NIH reports that research into the blood pressure-regulating benefits of magnesium supplements have found that the mineral likely only lowers blood pressure to a small extent.
Although magnesium deficiency serious enough to cause symptoms is rare in the U.S., many people dont consume enough magnesium on a regular basis. One study found that 48% of Americans dont get enough magnesium from their diets. If you have low magnesium, your doctor may recommend a supplement to address the deficiency.
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Big Doses Of Vitamin C May Lower Blood Pressure
Taking large doses of vitamin C may moderately reduce blood pressure, according to an analysis of years of research by Johns Hopkins scientists. But the researchers stopped short of suggesting people load up on supplements.
Our research suggests a modest blood pressure lowering effect with vitamin C supplementation, but before we can recommend supplements as a treatment for high blood pressure, we really need more research to understand the implications of taking them, says Edgar Pete R. Miller III, M.D., Ph.D., an associate professor in the division of general internal medicine at the Johns Hopkins University School of Medicine and leader of the study published in the American Journal of Clinical Nutrition.
Roughly 30 percent of adults in the United States have high blood pressure, or hypertension, an important risk factor for heart disease and stroke. Successful treatment may include drugs, exercise, weight loss, and dietary changes such as reducing salt intake. Some experts believe that large amounts of vitamin C, an essential micronutrient found primarily in fruits and vegetables, could lower pressure as well, but randomized, controlled dietary intervention studies the gold standard of nutrition research have produced mixed results.
Five hundred milligrams of vitamin C is the amount in about six cups of orange juice. The recommended daily intake of vitamin C for adults is 90 milligrams.
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Proteins Peptides And Aminoacids
A metaanalysis of 40 RCTs including 3277 participants showed that, compared with carbohydrate, dietary protein intake was associated with significant changes in mean SBP and DBP, of 1.8 mmHg and 1.2 mmHg, respectively 29. Both vegetable protein and animal protein were associated with significant BP changes of 2.3 mmHg and 2.5 mmHg, respectively, for SBP and 1.3 mmHg and 0.9 mmHg, respectively, for DBP 29.Part of the BPlowering effect might have been caused by a component of the vegetable protein source other than protein. In particular, soy isoflavones are associated with a significant decrease in SBP and DBP in hypertensive subjects 30.
A rich natural source of peptides and amino acids is whey. Studies in animals and humans have shown that lactalbumin and lactoglobulin obtained from enzymatically hydrolysed whey inhibit angiotensinconverting enzyme , while lactorphins lower BP by normalizing endothelial function or by an opioid receptordependent mechanism 31.
Milk peptides have variable BPlowering effects, which are more evident in Asian subjects 33, 34.These peptides may also improve pulse wave velocity in mildly hypertensive subjects 35. No safety concerns were raised 35.
Some fish have also been found to contain peptides with powerful ACE inhibitory activity, inducing a significant reduction in BP of around 9 ± 3/4 ± 1 mmHg in single clinical trials carried out in bonito, sardines, tuna and mackerel 36.
Vitamin K And High Blood Pressure
Vitamin K is the name for a group of compounds involved in blood clotting and distributing calcium throughout the body. There are two main types: K1 and K2. Menaquinone-4 and menaquinone-7 are two forms of vitamin K2.
Some scientists believe that low levels of vitamin K2 may lead to an increase in calcium deposits in the arteries, which can increase blood pressure and contribute to heart disease. However, there have not been many studies to investigate K2 MK4 or K2 MK7 and high blood pressure control. More research is necessary to explore the hypothesis that vitamin K2 may be beneficial for high blood pressure or heart disease.
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Is There Any Risk Of Taking Vitamins For Low Blood Pressure
Hypotension or low blood pressure sometimes occur as a side effect of medications and diet intended to treat hypertension or high blood pressure. In such cases, individuals must avoid certain food items such as fish oil and green coffee bean extract, which further lower blood pressure levels.
Though supplements help to raise blood pressure levels, those must be taken as per the doctors recommendation.
Individuals can maintain a proper diet and prevent adverse consequences with the above discourse on how vitamins affect blood pressure and help to regulate blood flow. Also, make sure to consult a healthcare professional and adjust your vitamin intake accordingly to ensure normal blood pressure.
Mixing Medications And Dietary Supplements Can Endanger Your Health
Dietary supplements may contain ingredients that can have strong effects in the body. Talk with a health care professional before taking supplements.
When you take prescription or over-the-counter medications, do you also take a vitamin, mineral, or other dietary supplement? Have you considered whether there is any danger in mixing medications and dietary supplements?
There could be. Certain dietary supplements can change absorption, metabolism, or excretion of a medication. If that happens, it can affect the potency of your medication, which means you may get either too much or too little of the medication you need.
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