Nsaids Can Increase Blood Pressure Within 4 Weeks
A study involving 787 people with both hypertension and osteoarthritis, assessed the effects of starting ibuprofen on their blood pressure control . Taking ibuprofen for four weeks, at the commonly prescribed dose of 600 mg three times daily, significantly worsened blood pressure control especially in those taking an angiotensin receptor blocker or an ACE inhibitor antihypertensive drug.
- In people receiving angiotensin receptor blockers antihypertensive therapy, systolic blood pressure readings worsened by 8.1 mmHg when taking ibuprofen .
- For patients receiving an ACE inhibitor, the estimated increase in blood pressure due to ibuprofen was 8.2 mmHg.
- In those taking a beta-blocker, the increase in blood pressure was 5.8 mmHg.
- For patients taking a diuretic ibuprofen caused blood pressure to rise by 3.6mmHg.
- For those on a calcium channel blocker, taking ibuprofen for 4 weeks caused systolic blood pressure to increase by 2.8mmHg.
Talk With Your Doctor
Ibuprofen can be a safe and easy over-the-counter remedy for minor aches and pains. However, if you dont use it as recommended, ibuprofen can possibly be harmful.
Its always smart to talk to your doctor before taking ibuprofen if youre not sure if you should use it. If you experience bothersome side effects or believe you may have taken too much, contact your doctor right away.
Most of the serious side effects result from taking the drug when you shouldnt, taking too much of it, or taking it for too long. You can reduce your risk of side effects by using the smallest possible dose for shortest possible time.
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Research Reveals Why You Shouldn’t Take Ibuprofen With Blood Pressure Meds
There are new warnings being raised about combining ibuprofen with certain types of blood pressure medications. The combination may lead to permanent kidney damage.
A new report from The University of Waterloo suggests that combining ibuprofen with a diuretic and a renin-angiotensin system inhibitor for high blood pressure could place people at risk for kidney disease. Diuretics and RSA inhibitors are commonly prescribed together for people with hypertension and are available under various pharmaceutical brand names.
Researchers from the University of Waterloo in Ontario examined the interaction of the three types of commonly-used medications. Through the use of computer-simulated drug trials, the research team found that in certain patients with specific medical profiles, the combination of all three medications can lead to acute kidney injury. And, in some cases, the injury caused by the medicine combination can be permanent, the researchers said.
The use of computer-simulated drug trials was selected by the University of Waterloo team because it can more quickly provide results than in-human studies. The university noted that its team combined mathematics and computer science in order to offer medical practitioners a head start with issues like drug complications.
The research was presented in the journal Mathematical Biosciences. In addition to Layton, the paper was co-authored by Jessica Leete, Carolyn Wang and Francisco J. López-Hernández.
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Risks And Side Effects Of Nsaids
The most common general side effects of NSAIDs are nausea, stomach upset and heartburn, according to the University of Wisconsin-Madison School of Medicine and Public Health . It’s important to note that you do not take it on an empty stomach, and you should not use NSAIDs for more than 10 days without speaking with your doctor.
UW Health notes that NSAIDs can also increase your risk of stroke, heart attack, internal bleeding and other health problems. People over age 65 and those with heart, liver, stomach, intestinal diseases or kidney diseases face greater risk of problems that may come with taking NSAIDs.
And if you’re pregnant or breastfeeding, you should consult with your doctor about whether you can take NSAIDs.
UW Health says you should also speak with your doctor if you want to take NSAIDs and have any of the following:
- Bleeding problems.
- Stomach pain or upsetstomach.
- Ulcers or a history ofintestinal or stomach bleeding.
- Heartburn.
- A habit of consumingmore than three alcoholic beverages per day, which can increase your risk ofstomach bleeding.
- Heart, kidney or liverdisease.
Kidney Complications Could Be Connected To Dehydration
According to the study’s corresponding author, Anita Layton, PhD, Canada 150 Research Chair in mathematical biology and medicine and professor of applied mathematics, computer science, pharmacy, and biology at the University of Waterloo, the risk of acute kidney injury may have something to do with the amount of water in your body.
“Diuretics are a family of drugs that make the body hold less water,” Layton said in a press release outlining findings. “Being dehydrated is a major factor in acute kidney injury, and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy.”
The “triple whammy” she refers to occurs when a patient is taking all three medications, and study data suggests that low water intake, myogenic response , and drug sensitivity may increase the risk that patients with hypertension experience this dangerous complication.
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Who May Not Be Able To Take Ibuprofen
Do not take ibuprofen by mouth or apply it to your skin if you:
- have ever had an allergic reaction or symptoms like wheezing, runny nose or skin reactions after taking aspirin, ibuprofen or other non-steroidal anti-inflammatory drugs such as naproxen
- are pregnant
To make sure ibuprofen tablets, capsules, granules or liquid is safe for you, tell your doctor or pharmacist if you:
- have ever had bleeding in your stomach or a hole in your stomach caused by an NSAID
- have had a hole in your stomach, bleeding in your stomach or a stomach ulcer more than once
- have a health problem that means you have an increased chance of bleeding
- have severe heart failure, severe kidney failure or severe liver failure
- are trying to get pregnant
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Ibuprofen And Cardiovascular Safety
Ibuprofen is a non-steroidal anti-inflammatory drug used for the relief of acute and/or chronic pain and inflammation.
Medsafe and the Medicines Adverse Reactions Committee have concluded that there is a small increased risk of cardiovascular thrombotic events with ibuprofen, when used at high doses and in long-term treatment. Overall, the studies suggest that lower doses of ibuprofen , the dose generally used for over-the-counter preparations, are not associated with this increased cardiovascular risk.
Information for consumers and caregivers
- Non-steroidal anti-inflammatory drugs , including ibuprofen, are effective at relieving pain and inflammation .
- For most people, taking ibuprofen is safe. However, you should check with your healthcare professional that this medicine is appropriate if you:
- have high blood pressure
- have current or a history of heart failure or heart disease.
Information for healthcare professionals
Can You Take Blood Pressure Meds With Ibuprofen
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Ibuprofen Can Interact With Medications
Youre more prone to negative effects if youre taking other medications that ibuprofen doesnt mix well with.
Ibuprofen can interact with the meds youre on, especially high blood pressure medications, which can lead to some serious adverse effects, Dr. Morgan says. That could be deadly.
Ibuprofen can interact negatively with:
- Heart medication, such as clopidogrel.
- Immunosuppressive medication, such as cyclosporine.
- Seizure medication, such as phenytoin.
- Other NSAIDs.
Ibuprofen can impact certain conditions
You should also check with your doctor before taking ibuprofen if you have any of the following conditions:
- Gastrointestinal problems, including heartburn.
- Pregnancy.
How much ibuprofen is safe?
How much ibuprofen you can take depends on, well, you. Theres not really a one-size-fits-all answer, Dr. Morgan says. It depends on your general state of health.
As a general rule, though, Dr. Morgan says most healthy people those who dont have high blood pressure or gastrointestinal issues can typically take ibuprofen on a limited basis to address minor aches and pains.
Its not without risk, but you can feel pretty safe taking it for about three days, she says. Take no more than 400 to 600 milligrams, three times a day, with food. Otherwise, it can ruin your stomach.
Nsaids Reduce The Effectiveness Of Antihypertensive Drugs
In people whose blood pressure was previously controlled on medication, starting an NSAID can worsen their blood pressure readings. The size of this effect depends partly on the individual and on the blood pressure medication they are taking.
When researchers checked the records of 1,340 people with hypertension who used NSAIDs and 1,340 people who used acetaminophen , they found that NSAID use was associated with a 2 mmHg higher systolic blood pressure overall. In those taking an ACE inhibitor or calcium channel blocker to control their hypertension, NSAID use increased systolic blood pressure by an average of 3 mmHg. In those taking a beta-blocker antihypertensive drug, systolic blood pressure was 6 mmHg higher, on average.
Previous studies have reported as much as a 7 mmHg increase in blood pressure in people who take an NSAID such as ibuprofen plus a beta-blocker drug, and up to a 10 mmHg rise in blood pressure in people combining ibuprofen with an ACE inhibitor drug.
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So Which Painkiller Is Best If You Have High Blood Pressure
If you have high blood pressure and a painful condition such as osteoarthritis, which requires regular non-steroidal anti-inflammatory painkiller, whatever you do, avoid taking ibuprofen. Talk to your doctor about whether or not another type of painkiller might suit you better.
Bear in mind that pain, in itself, can raise blood pressure, so it is important to find a safe way to control your symptoms. A topical pain-relieving cream or gel is worth trying, for example. The amount of diclofenac absorbed through the skin when using a Voltarol gel is a drop in the ocean compared to the amount absorbed into the circulation when taken by mouth. Having said that, read the Voltarol Emulgel Patient Information Leaflet within the pack carefully, as applying the gel to multiple sites is not recommended, and the area covered is usually just the zie from 1 penny to a 2 pence piece! If you overuse Voltarol Gel, your blood pressure could well go up so monitor it carefully. Paracetamol is also effective for some people, but not for others.
Whenever you start a new medicine its vitally important to monitor your blood pressure regularly to see if your hypertensive control changes.
If your blood pressure is raised, self-monitoring is key to maintaining good control.
Image credits: pixabay
What Are The Risks
NSAIDs are bad for your blood pressure.
NSAIDs can cause high blood pressure. And if you have high blood pressure, they can make it worse. This increases your chances of having a heart attack or a stroke.
NSAIDs can also keep some blood pressure drugs from working right. NSAIDs can interfere with:
- Diuretics, or water pills, such as apo-Hydro .
- Diuretics remove excess water from the blood vessels.
- ACE inhibitors, such as Altace and Coversyl .
- ACE inhibitors are drugs that relax the blood vessels.
- ARBs such as Cozaar . ARBs are another group of drugs that relax the blood vessels.
NSAIDs are bad for your heart and kidneys.
Long-term use of NSAIDs can make your body hold onto fluid. This can worsen the symptoms of heart failure, such as shortness of breath, swollen ankles, and a rapid or irregular heartbeat. NSAIDs can also keep the kidneys from working well. This makes taking NSAIDs risky for people who already have kidney disease.
Which painkillers can you use if you have heart or kidney disease?
There is no simple answer. The best painkiller to use depends on your health problems. It also depends on any other drugs you take. Be sure to tell your health care provider about any prescription drugs, over-the-counter drugs, or herbal medicines you take.
Over-the-counter Tylenol is often the best choice for people with high blood pressure, heart failure, or kidney problems.
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