What Is Coenzyme Q10
Found in almost every cell of the body, CoQ10 is a fat-soluble, vitamin-like substance that helps convert food into energy. A powerful antioxidant that protects against damage from toxic free radicals, CoQ10 is produced by the body and is also found in many foods, with higher levels in organ meats, such as liver or kidneys as well as sardines, mackerel, chicken, cauliflower, broccoli and asparagus.
But More Research On Coq10 Needed To Establish Its Impact
While the results so far on CoQ10s ability to counter high blood pressure have been encouraging, experts warn that more wellconducted trials are required to back up these claims. On the flip side, according to some other researchers, there is some moderate quality evidence that suggests the coenzyme doesnt actually help bring down blood pressure. They also cite unacceptably high risk of bias in the studies that do suggest its benefits for hypertension. Further trials will, therefore, be needed to establish CoQ10s potential in lowering blood pressure.16 Until then, no specific dosage can be recommended to assure specific benefits for hypertension.
That said, many experts endorse that CoQ10 can be considered a safe dietary supplement. If you do decide to give it a try after consulting your doctor, heres what you should know about CoQ10 dosage for hypertension in studies. Animal studies indicate that consuming CoQ10 at a rate of 12mg/kg/day should be fine.17 Other studies confirm that a typical 55 kg adult could tolerate as much as 660 mg a day of CoQ10. Most people take it as a supplement of between 90 mg to 200 mg on average, so there shouldnt be any risk of toxicity or adverse side effects.18Your dosage may be higher depending on your current health condition, weight, and medical history. Some experts are known to suggest doses of 200300 mg for blood-pressure-lowering effects.
Coenzyme Q10 Is Needed For Energy Production
Coenzyme Q10 is a vitamin-like substance present in most body cells, where it is needed for the production of energy within the mitochondria, cell structures which act rather like batteries. Cells which work the hardest have the most mitochondria and the highest need for coenzyme Q10 especially muscle cells such as those in your heart.
Derived from: Kahn et al. Lipids 1989 24:579-584
After the age of 20, your blood levels of coenzyme Q10 begin to fall for two reasons: you absorb dietary coenzyme Q10 less efficiently, and the amount made in your cells start to decline. By the age of 40, the amount of coenzyme Q10 present in heart muscle and artery lining cells is up to 32% lower than when you were in your 20s, for example, and by the age of 80 has halved again.
Without coenzyme Q10, cells cannot produce energy as well as normal and function less efficiently. Muscle cells in artery linings are less able to dilate and contract to normalise blood pressure and, when levels become significantly low, heart muscle contraction is impaired.
Research suggests that falling coenzyme Q10 levels play a significant role in age-related medical conditions such as hypertension, coronary heart disease, heart attack and heart failure.
Biopsies from patients with various forms of heart disease have shown that up to 75 per cent are deficient in coenzyme Q10, and lower levels of coenzyme Q10 are associated with more severe heart disease.
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Can You Take Coq10 With High Blood Pressure Medication
Taking CoQ10 with high blood pressure medication is not recommended. You should talk to your doctor before taking this supplement. If your doctor recommends CoQ10 as a treatment for hypertension, you should discontinue any high blood pressure medications and speak to the doctor about dosage, side effects and if there are interactions between these drugs.
How Should I Take Ubiquinone
When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.
If you choose to use ubiquinone, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.
Measure liquid ubiquinone carefully. Use the dosing syringe provided, or use a medicine dose-measuring device .
To take the disintegrating tablet, use dry hands to remove the tablet from the package, and place it in your mouth. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Do not use different forms of ubiquinone at the same time without medical advice. Using different formulations together increases the risk of an overdose.
Your blood pressure may need to be checked while you are taking ubiquinone.
If you need surgery, stop taking ubiquinone at least 2 weeks ahead of time.
Store ubiquinone at room temperature, away from light, heat, and moisture. Keep the medicine bottle closed when not in use.
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Five Key Things To Remember About Coq10
How Much Coenzyme Q10 Should I Take To Lower Blood Pressure
Coenzyme Q10 also known as CoQ10 is a fundamental component of some regular body functions and is required by each and every cell in the body. As an antioxidant agent that shields cells from the impacts of aging, CoQ10 has been utilized as a part of therapeutic practices for a considerable length of time, particularly as the treatment for heart issues.
Despite the fact that CoQ10 is produced in the body and found in numerous dietary sources, a lack of coenzyme Q10 can happen in the body. Coenzyme Q10 insufficiency is regularly connected with cardiovascular conditions, for example, strokes, heart attacks, increase in cholesterol level and blood pressure. Utilizing CoQ10 as a supplement may help counter these cardiovascular issues.
The name may not sound common, but still, CoQ10 is a fundamental supplement. In its active mode, it is known as ubiquinol or ubiquinone. It is integrated into the body naturally for controlling blood pressure levels, providing energy to the cells, and transporting electrons. The reason for not acknowledging it to be a vitamin is that all creatures, comprised of humans, can make little quantity of coenzymes by themselves even without the need of any nourishment.
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Medications For High Blood Pressure Interacts With Coenzyme Q10
Coenzyme Q10 seems to decrease blood pressure. Taking coenzyme Q10 along with medications for high blood pressure might cause your blood pressure to go too low.Some medications for high blood pressure include captopril , enalapril , losartan , valsartan , diltiazem , Amlodipine , hydrochlorothiazide , furosemide , and many others.
Can Coq10 Lower Your Blood Pressure
Can Coq10 Lower Your Blood Pressure? In one analysis, after reviewing 12 clinical studies, researchers concluded that CoQ10 has the potential to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 mm Hg, without significant side effects. More research with greater numbers of people is needed.
What medications should not be taken with CoQ10? Possible interactions include: Anticoagulants. CoQ10 might make blood-thinning drugs, such as warfarin , less effective. This could increase the risk of a blood clot.
Are there any side effects associated with coenzyme Q10 treatment? While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure.
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Does Coq10 Help To Lower Blood Pressure Levels
There is some preliminary evidence that suggests CoQ10 may help to lower blood pressure levels in people with hypertension. However, more research is needed to determine if this is an effective treatment. If you have hypertension, you may want to consider talking to your doctor about taking CoQ10 supplements.
Will Coq10 Lower Blood Pressure
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Coq10 Lowers Blood Pressure
High blood pressure is a major risk factor for both heart attacks and strokes, and so managing it is of critical importance.
People with high blood pressure tend to have lower levels of CoQ10.
For an article published in the Journal of Hypertension, experts from the University of Rochester did a meta-analysis , and found evidence that the enzyme does have hypertension-lowering qualities.
In fact, at least 12 studies have shown that CoQ10 decreases blood pressure. It is thought to do so through its mechanism as an antioxidant and also improving the function of blood vessels by preserving nitric oxide.
In an eight-week, double-blind study of 59 men already taking medications for high blood pressure, researchers found that the group taking CoQ10 experienced a 9 percent drop in their blood pressure readings compared to the men who were taking a placebo.
Similar results were found in a 12-week, double-blind study of 83 people with isolated systolic hypertension .
A study of 74 people with diabetes also produced a similar result.
Finally, a study of 109 patients with long-standing, essential hypertension, who were all taking medication, found that CoQ10 improved their hearts function, allowing about half of them to discontinue most of their blood pressure medications.
In that study, those who took CoQ10 experienced an average decrease of systolic blood pressure from 159 to 147 mm Hg, and a diastolic pressure decrease from 94 to 85 mm Hg.
Why It Is Important To Do This Review
Many people take CoQ10 for hypertension, cardiovascular health, or both. A nonCochrane review concluded that CoQ10 reduced blood pressure . However, in that review, there was no reported assessment of the risk of bias in the included trials. The first version of this review was completed and published in October 2009, and concluded that “due to the possible unreliability of the three included studies, it is uncertain whether or not CoQ10 reduces blood pressure in the longterm management of primary hypertension” . The present update of this systematic review uses the latest Cochrane methodology to assess the blood pressure lowering effect of different doses of CoQ10. The information derived from this review should assist clinicians in determining whether or not it is worth trying CoQ10 as a therapeutic intervention to lower blood pressure, and to help determine whether further studies that measure cardiovascular outcomes should be conducted.
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What Are The Treatments Available For Hypertension
There are many treatments available for hypertension, including medication, lifestyle changes, and surgery. Some people may also benefit from taking CoQ10 supplements to help lower their blood pressure levels. CoQ10 is a natural antioxidant that is found in every cell of the body. It helps to produce energy and plays a role in maintaining cardiovascular health. Preliminary research suggests that CoQ10 may help to improve blood pressure levels in some people who have hypertension. More research is needed to determine if CoQ10 is an effective treatment for this condition.
Reducing High Blood Pressure With Natural Therapies
In day-to-day practice, many practitioners encounter patients with hypertension problems that are not being managed effectively. Some patients in fact discontinue with their prescribed medications because of the undesirable side effects, or for other reasons.
As natural health practitioners, we are often asked if there are any dietary supplements or nutritional therapies that can lower blood pressure in a more natural way without producing unwanted side effects. Research studies conducted over the past 15 years support the use of specific dietary and supplementation practices, and participation in physical activity as natural interventions to reduce high blood pressure. In some cases these natural solutions are all that are required to control blood pressure in other cases theses practices can significantly lower the requirement for medication, helping to reduce the likelihood of adverse side effects occurring from the use of these drugs.
Trends in Hypertension
Hypertension, hypercholesterolemia and cigarette smoking are considered the cardinal risk factors for cardiovascular disease. Studies indicate that lowering a patient’s blood pressure from 160/90 to 140/80 mmHg may decrease risk of heart disease by more than 30 percent.
Effective Nutritional Therapies and Lifestyle Interventions
Weight loss – Usually, only 10-15 lbs. of weight loss will produce a significant blood pressure reduction in hypertensive patients.
Magnesium supplementation – 600 mg per day .
Does Coenzyme Q10 Lower Cholesterol
Having high cholesterol increases your risk for the number one cause of death in the United States — heart disease. Taking steps to lower your cholesterol levels, especially your LDL and total cholesterol, helps keep your arteries from becoming blocked and causing a heart attack. People with high cholesterol tend to have lower levels of coenzyme Q10 compared to those of healthy people. However, taking CoQ10 supplements doesn’t lower your cholesterol, according to the University of Maryland Medical Center.
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What Happens When You Take Coq10 Everyday
Coenzyme Q10 has been linked to improved aging, exercise performance, heart health, diabetes, fertility and migraines. It may also counteract adverse effects of statin medications. Typically, 90200 mg of CoQ10 per day are recommended, though some conditions may require higher dosages of 300600 mg.
Fish Oil Supplements Coq10 And Your Heart
Feb 16, 2022Jasmine Aimaq
Fish oil. CoQ10. These are just two of the supplements Americans spend billions of dollars on each year, hoping to up their health game and prevent or treat medical conditions. Do these natural aids do any good? More importantly, can they do harm?
The answer to both questions is a qualified yes. Fish oil and CoQ10 do provide benefits, but if you take too much of them or combine them with other drugs, you may actually increase your risk of problems. Let’s have a closer look at them.
“Taking more than one gram of fish oil per day is something you should only do following your doctor’s advice.”
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Coenzyme Q10 For High Blood Pressure
Coenzyme Q10 improves the elasticity and reactivity of artery walls. Adding 225 mg coenzyme Q10 to existing anti-hypertensive treatment was found to produce significant, gradual improvements in blood pressure in a study involving 109 people with hypertension. As a result, just over half were able to stop between one and three of their antihypertensive drugs within 4.4 month after starting coenzyme Q10. Those whose heart contraction was assessed also showed a significant improvement in left ventricular wall thickness and function so heart pumping became more efficient. Only three per cent of patients required the addition of one antihypertensive drug despite coenzyme Q10 treatment.
The results from 3 trials, involving 96 people, found that in people with high blood pressure, taking coenzyme Q10 supplements reduced their readings, on average, by 11/7 mmHg compared with inactive placebo.
A larger analysis, using data from 12 clinical trials, involving over 360 people, found that coenzyme Q10 reduced blood pressure by up to 16.6/8.2 mmHg compared with placebo. This included a cross-over trial, in which the same group of people took coenzyme Q10 or placebo for a period of time, then crossed over to take the other treatment . Their blood pressures were, on average, 11/8 mmHg lower when they were taking the coenzyme Q10 supplements than when they were taking placebo, and there were no significant side effects.