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How Do Diuretics Lower Blood Pressure

How Much Does A Diuretic Lower Blood Pressure

How do Diuretics Lower Blood Pressure

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Similarly one may ask, how long does it take a diuretic to lower blood pressure?

You usually take gentle, long acting diuretics by mouth once each day in the morning. The effects of bendroflumethiazide start within 1-2 hours of taking and can make you pass more urine for the first 14 days when taking it.

Beside above, are Diuretics good for high blood pressure? Diuretics for Hypertension. Diuretics, also known as water pills, belong to a class of medications that remove excess salt and water from the body. They are often used to treat hypertension, or high blood pressure. High blood pressure can be a contributing factor in the development of various forms of heart disease.

Accordingly, how does a diuretic lower blood pressure?

They work on your kidneys by increasing the amount of salt and water that comes out through your urine. Too much salt can cause extra fluid to build up in your blood vessels, raising your blood pressure. Diuretics lower your blood pressure by flushing salt out of your body, taking this unwanted extra fluid with it.

What is the best water pill for high blood pressure?

Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure.

Risks And Side Effects

Diuretics are generally safe for most people when taken as prescribed.

The most common side effect of diuretics is increased urination. Your potassium, glucose, and cholesterol levels may fluctuate depending on the type of diuretic youre taking. Your doctor may run blood tests to measure your levels throughout treatment.

Other common side effects can include:

  • headaches

More severe side effects can include:

Side effects are likely to decrease over time. Make sure to notify your doctor if you experience uncomfortable or prolonged side effects while taking a diuretic. Your doctor may adjust your dosage or switch you to a different type of diuretic medication.

Analysis Of Genetic Variants

Furthermore, variation in genes involved in thiazide response could provide a link associating these genes with thiazide blood pressure-lowering mechanisms. One such candidate gene, SCNN1G , has previously been implicated in the thiazide blood pressure response. Those with polymorphisms in SCNN1G experienced a larger blood pressure response to HCTZ than those without . Since thiazides may indirectly influence ENaC activation via the decrease in luminal calcium concentrations , ENaCs role in the thiazide-induced blood pressure response should be investigated further.

Another gene, WNK1 , has also been associated with the blood pressure response to thiazides. Patients with polymorphisms in WNK1 achieved greater blood pressure lowering from HCTZ than those without WNK1 polymorphisms . This finding is potentially important because WNK1 has been associated with an increase in NCC activity , which perhaps strengthens the evidence linking NCC to thiazide chronic blood pressure lowering. Thus, the exploration of WNK1 as a mechanistic candidate gene for thiazide response is warranted.

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Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

  • frequent urination
  • ongoing pain that begins in the stomach area, but may spread to the back
  • joint pain or swelling
  • changes in vision, eye pain, or swelling or redness in or around the eye

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

What Are Thiazide Diuretics

Antihypertensives

A diuretic is a medicine which increases the amount of water that you pass out from your kidneys. So, they are sometimes called ‘water tablets’. There are different types of diuretics which work in different ways and thiazide diuretics are one type of diuretic.

Thiazide diuretics are a common treatment for high blood pressure . They are also used to clear fluid from the body in conditions where your body accumulates too much fluid, such as heart failure.

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Why It Is Used

Thiazide diuretics are recommended as the first line of treatment for high blood pressure. They are usually recommended as one of at least two medicines to control high blood pressure.

Quinazoline diuretics are similar to the thiazide diuretics, but are used only in certain people such as those with kidney problems and when other diuretics have not worked.

Loop diuretics are prescribed for people who also haveheart failure, kidney problems, or swelling in their legs .

Potassium-sparing diuretics might be used, along with other diuretics, if you have low potassium levels.footnote 1

What Is The Best High Blood Pressure Medication

Selecting the “best” high blood pressure medication depends on several things, including the general health of the patient, his or her age, ethnicity, and whether or not they have any co-existing medical issues or drug sensitivities.

For example, in a hypertensive patient with asthma, it may be inadvisable to prescribe a beta-blocker, as these drugs can aggravate that respiratorycondition. Similarly, in patients prone to constipation use of certain calcium channel blockers might best be avoided — along with diuretics — as both these classes of drugs can inhibit proper bowel function.

African-American patients respond to some antihypertensive medications better than others.

Certain groups of patients require the use of a specific class of high blood pressure medication. These include:

Pregnant Women

  • The drug of choice for hypertensive, pregnant women is one of the oldest high blood pressure medications on the market. Methyldopa, which works to lower blood pressure through the central nervous system, has the lowest risk of harming the mother and developing fetus.
  • Other possible safe options include labetalol, beta-blockers, and diuretics.
  • Two classes of drugs that should never be used during pregnancy include ACE inhibitors and angiotensin II receptor blockers.

African-Americans

Elderly Patients

With age, comes an increased risk for systolic hypertension which can be aggravated by severe atherosclerosis.

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Can Water Pills Help With High Blood Pressure

The drugs, which are also known as water pills, are widely used to treat heart failure and lower blood pressure. The most common and least expensive type of blood pressure medication is diuretics, also known as water pills. In addition to helping the kidneys eliminate sodium and water from the body, they also help to eliminate waste products.

  • 9. what is the best natural diuretic for high blood pressure?
  • Drugs Vs Lifestyle Change

    Diuretics and how they effect blood pressure

    First, keep in mind that drugs have limited success. Most studies on diuretics and other blood pressure-lowering drugs suggest they lower the risk of cardiovascular events among those with blood pressure between 140/90 and 159/99 by 15 to 20%.3 The problem is, with this range of blood pressure, the risk of cardiovascular-related deaths has increased by 300 to 400% compared to people with normal blood pressure.

    So, while treating hypertension with drugs is generally better than no treatment, it is far from a cure, asserts Dr. Fruge.

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    How Are Water Pills Used To Treat High Blood Pressure

    Water Pills for High Blood Pressure. Loop diuretics are drugs that prevent the reabsorption of sodium into the blood. Their effect is seen in the loop of Henle of the kidneys which is why such pills are called loop diuretics. Thiazide pills dilate the blood vessels and lower the amount of sodium and water in the body.

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    I used to think these dramatic drops in blood pressure were something that happened to only a very few people, continues Dr. Fruge, but Ive been here at Pritikin for more than 15 years, and I see results like these every week. This isnt a miracle. Its simply what happens when we start taking good care of ourselves.

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    Diuretics And Low Blood Pressure

    Fact Checked

    Diuretics, also called water pills are drugs used to treat edema or water retention caused by such medical conditions as high blood pressure, heart failure, glaucoma, kidney failure and ascites 124. Ascites is the accumulation of fluids in the abdominal cavity due to liver disease. Diuretics work by preventing the kidneys from reabsorbing sodium, which leads to increased removal of sodium and water from the body.

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    What To Think About

    You may feel more tired or need to urinate more often when you start taking this medicine. These effects typically occur less after you have taken the medicine for a while. If the increase in urine interferes with your sleep or daily activities, ask your doctor to help you plan a schedule for taking the medicine.

    Ask your doctor if you need to take a potassium supplement or if you need to watch the amount of potassium in your diet. If you take a loop diuretic or thiazide diuretic, your doctor may suggest you get extra potassium, because these medicines lower your potassium levels. But if you take a potassium-sparing diuretic, you do not need to get extra potassium in your diet.

    For tips on taking blood pressure medicine, see:

    High Blood Pressure: Taking Medicines Properly.

    All Thiazide Drugs Are Useful For Lowering Blood Pressure

    Theres a choice of thiazides that do a jolly good job of lowering blood pressure at the lowest dose!

    Chlortalidone was first marketed as a diuretic in 1960, and it is referred to as a thiazide-like diuretic because it does not have quite the same chemical structure as the rest. It has largely fallen out of use in the UK, though in fact it is has a very good BP-lowering effect which is not dose-dependent, so low doses such as 25mg daily can be used. Hydrochlorothiazide appeared at the same time, but by contrast it has an action on BP which is dose dependent. In that respect it differs from all the other thiazides subsequently marketed for hypertension. All of the rest work equally well at the lowest dose. Thiazides have shown different patterns of adoption in different countries. The British favourite, over three decades, was bendroflumethiazide, which is unfortunate, since it has the weakest evidence base.

    The overall message from the review is that all the thiazides are useful drugs for hypertension, typically dropping systolic BP by 9 mm Hg with a single daily dose. In the case of chlortalidone, the effect may be nearer 12 mm Hg.

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    How To Take It

    Furosemide doesn’t usually upset your tummy so you can take it whether or not you’ve eaten recently.

    Swallow the tablets whole with a drink of water.

    If you’re taking furosemide as a liquid, it will come with a plastic spoon or syringe to help you measure out the correct dose. If you don’t have one, ask your pharmacist for one. Do not measure the liquid with a kitchen teaspoon as it won’t give the right amount.

    Some people take furosemide mixed with other diuretics or potassium:

    • with amiloride
    • with spironolactone
    • with triamterene
    • with potassium

    What If I Take Too Much

    Diuretics for Hypertension (high blood pressure), Heart Failure, or Fluid Overload

    Too much furosemide can cause headaches, dizziness, a pounding or irregular heartbeat and fainting. You may also pee more than normal and feel thirsty.

    The amount of furosemide that can lead to an overdose varies from person to person.

    Urgent advice: Call your doctor or go to A& E straight away if:

    You take too much furosemide and:

    • you feel unwell
    • you are over 65
    • you have kidney, liver or heart failure

    Find your nearest A& E department. If you go to hospital, take the furosemide packet, or the leaflet inside it, plus any remaining medicine with you.

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    Research Needs To Find Out About Things That Matter To Patients

    Like most trials of the past, the thiazide trials concentrated on blood pressure and metabolic outcomes, but ignored what might be more important to patients. So if a man taking a thiazide has erectile problems, I dont know whether he would be best to try a different thiazide or a different drug class altogether. Thats the problem with evidence based medicine: its based on the evidence we have, and not on the evidence we would like to have. That needs to change, but it will be a long haul.

    About the Cochrane Collaboration

    Best Medication For Hypertension

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    Thiazide Diuretics For The Treatment Of High Blood Pressure

    High

    Thiazide diuretics are a class of drugs commonly recommended as first-line treatment for raised blood pressure because they significantly reduce death, stroke and heart attacks. This class includes bendrofluazide, chlorthalidone, cyclopenthiazide, hydrochlorothiazide, indapamide and metolazone. We asked by how much does this class of drugs lower blood pressure and whether there is a difference between individual drugs within the class. We searched the available scientific literature to find all the trials that had assessed this question. The data included in this review was up to date as of February 2014.

    We found 60 trials that randomly assigned 11,282 adult participants, mean age 55 years, 53% male and 47% female, with blood pressure above 140/90 mmHg to take one of six thiazide diuretics or placebo for an average duration of eight weeks. Most of the trials were published before the year 2000 and most were found to have a high risk of bias in the adverse effect data. Co-morbidities were not reported in most trials. The blood pressure-lowering effect was modest. Thiazide diuretics reduced blood pressure by 9 points in the upper number and 4 points in the lower number . Different thiazide drugs have similar effects in lowering blood pressure and thiazides lower systolic blood pressure more than other classes of antihypertensive drugs.

    We searched the Cochrane Central Register of Controlled Trials , Ovid MEDLINE , Ovid EMBASE and ClinicalTrials.gov.

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    Why Is This Medication Prescribed

    Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics . It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

    High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

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